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Passive Antibody Therapy

In 1890, Emil Behring and Shibasaburo Kitasato reported an extraordinary experiment. They immunized rabbits with tetanus and then collected serum from these animals. Subsequently, they injected 0.2 ml of the immune serum into the abdominal cavity of six mice. After 24 hours, they infected the treated animals and untreated controls with live, virulent tetanus bacteria. All of the control mice died within 48 hours of infection, whereas the treated mice not only survived but showed no effects of infection.

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